Aging Category

Free Radical-Induced Skin Damage

Customers with Free Radical-Induced Skin Damage as their category of highest need, either:

  • Produce an excessive level of free radicals; or,
  • Are unable to produce the necessary antioxidants to counter the damaging effects of the free radicals; or,
  • Both of these paths

Customers whose DNA profile predisposes them to increased skin damage caused by free radicals will be assigned the Antioxidation Serum.

Aperio Beauty’s personalized Antioxidation Serum, made specifically to counter free radical-triggered damage, is rich in numerous natural, plant-derived ingredients.  These ingredients both replenish natural antioxidants which are known to neutralize skin damaging free radicals, or counter the inflammatory mechanisms triggered by them, thereby providing each of an immediate protection against further damage and a sustained healing power on prior damage.  This results in a removal of fine lines and wrinkles, increased skin firmness and a restoration of your skin’s natural glow.

Free radicals are highly reactive molecules produced as a by-product of oxygen molecules, in response to intrinsic or environmental stressors, including UV radiation, smoking, physical or mental stress, or pollution. These reactive molecules, in turn, may damage a variety of structures in the body, with a pronounced negative impact on the skin.

Oxidation caused by free radicals is the primary path of skin damage and aging, causing premature cell membrane instability and damage, resulting in several possible physical signs of aging, including any of:

  • Fine lines, shallow, or even moderate, wrinkles and folds
  • Decreased skin firmness
  • Dull complexion with uneven texture and tone
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Aging Category

Skin Spots and Blemishes

Customers with Skin Blemishes as their category of highest need are more likely to have excess production of melanin in their skin.

Customers whose DNA profile predisposes them to skin blemishes will be assigned the Blemish Removal Serum.

Aperio Beauty’s personalized Blemish Removal Serum bears targeted ingredients that directly block overactive enzymes which cause skin blemishes.  Blocking these enzymes directly decreases synthesis of melanin while simultaneously blocking inflammatory pathways triggered by harmful UV radiation (upstream of excess melanin synthesis).  This drives both a removal of existing skin blemishes and a protection from the synthesis of new ones.

For most people, melanin is a protective pigment produced by the skin in response to the skin’s exposure to damaging UV rays from the sun.  This exposure drives your skin to produce more melanin to protect the skin.  As melanin production increases, our skin begins to tan and darken.

People whose variations predispose them to skin blemishes, over-produce melanin in the skin, resulting in the physical appearance of:

  • Freckles
  • Dark circles or spots
  • Irregular blemishes

Aging Category

Loss of Hydration

Customers with Loss of Hydration as their category of highest need are either:

  • Perpetually deficient in the retention or movement of moisture into the epidermis and upper layers of the dermis; or
  • Are deficient in stabilizing proteins between skin cells, thereby driving an excessive loss of moisture between the cells or from the cells themselves; or
  • Each of the above paths
Customers whose DNA profile predisposes them to perpetually dry skin will be assigned the Mass Moisture Serum.
 
Aperio Beauty’s personalized Mass Moisture Serum is rich in ingredients which both drive moisture back into dry skin as well as offer back essential proteins, helping to stabilize otherwise unstable cell to cell junctions, thereby retaining skin moisture.

Customers in this Loss of Hydration category are burdened by the appearance of perpetually dry skin, evidenced by:

  • Surface dryness and an uneven often cracked appearance
  • Dull complexion
  • Fine lines and wrinkles
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Aging Category

Inflammation-Induced Loss of Skin Elasticity

Customers with Inflammation-Induced Loss of Skin Elasticity as their category of highest need are more likely to have hyper-activation of otherwise naturally-occurring inflammatory pathways. These inflammatory pathways are in place to provide a protective barrier against various foreign bodies or skin pathogens, such as bacteria.

Customers whose DNA profile predisposes them to increased inflammation-induced loss of skin elasticity will be assigned the Skin Elasticity Serum.

Aperio Beauty’s personalized Skin Elasticity Serum is rich in natural, plant-derived ingredients which seamlessly saturate and block skin sensitizing inflammatory steps, at each of a given target as well as up-stream and down-stream of such targets. This restores your skin’s natural barrier function and protection, leading to a smooth, supple and elastic appearance.

Over-activity of such pathways, including NF-KB, TNF-alpha, and IL-1 among many others, changes the normal balance of natural skin defense mechanisms, inducing:
  • Decreased natural skin surface defense against pathogens
  • Diminished healing capacity of damaged skin
  • Overall increase in inflammation, resulting in excess production of dangerous free radicals
This increased inflammation, present for prolonged periods of time, manifests as visible signs of premature aging, including:
  • Redness of skin
  • Sensitivity to touch
  • Excess warmth

Over time, un-addressed inflammation-induced loss of skin elasticity may progress to features similar to those in free-radical induced skin damage, including:

  • Dryness and brittleness of skin, marked initially by an uneven texture and tone and progressing to breaks or a cracked appearance
  • Progression to fine lines, then to moderate and even deeper wrinkles
  • Decrease in skin firmness, driven by activation of collagen-degrading inflammatory pathways and enzymes

Aging Category

Decreased Skin Firmness

Customers with Decreased Skin Firmness as their category of highest need experience a decrease in the fullness of soft tissue structure in the dermis (the layer below the thin epidermis) lying deeper and supporting the structure of the skin.

Customers whose DNA profile predisposes them to decreased skin firmness will be assigned the Skin Firming Serum.

Aperio Beauty’s personalized Skin Firming Serum is rich in natural, plant-derived ingredients which decrease the activity of collagen-degrading enzymes, while also blocking specific inflammatory steps tied to decreased skin firmness.  Additionally, our Skin Firming Serum bears numerous ingredients which instill enhanced collagen and elastin elements, important in maintaining a natural, vibrant, full, and smooth skin appearance.

This decreased fullness is due primarily to either a decrease in new collagen synthesis, or to an excessive degradation of existing collagen. While some DNA variations predispose to decreased synthesis of new collagen, other DNA variations predispose to excessive degradation of natural collagen through over-activation of otherwise naturally-present, collagen-remodeling enzymes (i.e., namely matrix metalloproteinases, or “MMPs”).  Other DNA variations can lead to the activation of inflammatory pathways which degrade the firming structural components of the skin.

Collagen is the primary structural element in the dermis.  A natural remodeling of old collagen with new firmness and fullness of skin will be marked by an absence of fine lines and wrinkles. Customers whose SNP variations predispose decreased skin firmness may show one of several pronounced signs of aging, including, in increasing order of negative impact:

  • Loss of skin surface flexibility and elasticity
  • Fine lines or shallow wrinkles
  • Deeper wrinkles with loss of firmness
  • Major sagging of skin, most noted in the cheeks and neck
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Aging Category

Increased Sun Damage

Customers with Increased Sun Damage as their category of highest need manifest increased physical appearance of any combination of the following:
 
  • Uneven skin appearance
  • Decreased skin tone and loss of radiance
  • Increase in fine lines and wrinkles
  • Decreased skin elasticity
  • Decreased skin firmness
Customers whose DNA profile predisposes them to increased sun damage will be assigned the UV Repair Serum.
 
Aperio Beauty’s personalized UV Repair Serum is rich in a number of ingredients which counteract harmful impacts of UV radiation.  These ingredients include: growth factors, antioxidants, targeted inhibitors of inflammatory pathways and stabilizing membrane proteins, reversing all physical signs of increased sun damage.
These customers are at increased risk of UV radiation triggering:
  • Inflammatory pathways in the skin (e.g., NF-KB, IL-1, and TNF-alpha)
  • Increased activity of enzymes which degrade collagen and elastin, the primary proteins which sustain skin fullness and elasticity